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Nerium SkinCare ™ has developed skin care products based on an entirely new extraction process NBio-PL² ™ that combines the best of the Nerium oleander and Aloe Vera properties. We want to share what we've learned throug...h our development and testing of these new skin care products in terms of their ingredients and their effect. Research to date has shown these natural products are safe and, in terms of effectiveness, for many people better than what is available on the market today.

Nerium SkinCare's products are founded on the technology, core science, and continuing research of Nerium Biotechnology, Inc. (NBI).

NBI's research and new technology has provided Nerium SkinCare with the opportunity and ability to formulate and develop for the consumer an ever expanding pipeline of natural botanical skincare products. Products with specific targets have been identified and will focus initially on cosmetic applications for anti-aging, sun-damaged, blemished, and several specific skin conditions.

Development of the new breakthrough extraction technology by NBI has provided for a new patent-pending process NBio-PL² ™ to extract from these botanical compounds the active ingredients in a way that preserves their unique and beneficial properties. In October, 2009, Nerium Biotechnology, Inc. filed the new Nerium oleander-based extraction process NBio-PL² ™ to the US Patent and Trademark Office and PCT Patent Office (International). This extraction process incorporates pure liquid Aloe Vera to extract the unique Nerium oleander plant components in a way that preserves the unique and beneficial properties of both plants, without any additional solvents. The use of this natural extraction process combines the unique beneficial properties of the Nerium oleander and the known beneficial properties of Aloe Vera (NAE-8 ™ extract), and has allowed Nerium SkinCare to formulate and develop the "first of its kind" skincare products for topical applications. Learn more – NBI Core Science

Historical Use - Nerium oleander and Aloe Vera plants

Historical use of the Nerium oleander plant for medicinal applications has been reported in ancient texts and folklore for more than 1500 years. The Nerium oleander plant has been used traditionally as folk remedies for a wide variety of maladies and conditions, including dermatitis, eczema, psoriasis, herpes, sores, abscesses, warts, corns, skin cancer, ringworm, scabies, epilepsy, abortifacients, asthma, malaria dysmenorrheal, emetics, diuretics and heart tonics.

Within the past ten years there has been a substantial increase in the number of studies reported in peer-reviewed science journals that deal with the effects of cardiac glycosides (e.g. Nerium oleander extract and its components ... oleandrin) on the growth of human malignant tumor cells. From sponsored research at M. D. Anderson, our understanding of the spectrum of the pharmacologic activities of cardiac glycosides has increased significantly since the discovery of their effectiveness for treatment of congestive heart failure. It is now recognized that certain cardiac glycosides are involved in complex cell signal transduction mechanisms that may have important consequences in their application to the prevention and/or treatment of malignant diseases.

The Aloe Vera plant has been well known for centuries for its healing properties; the raw plant and commercial preparations can be used, and both oral intake and topical dressings have been documented to facilitate healing of any kind of skin wound, burn, or scald - even speeding recovery time after surgery. Historical use includes blisters, insect bites, rashes, sores, herpes, urticaria, athlete's foot, fungus, vaginal infections, conjunctivitis, sties, allergic reactions, and dry skin. Other topical uses include acne, sunburn, frostbite (it appears to prevent decreased blood flow), shingles, screening out x-ray radiation, psoriasis, preventing scarring, rosacea, warts, wrinkles from aging, and eczema.

Nerium SkinCare Product Formulation

Nerium SkinCare is dedicated to offering solutions that are based on proven science and actual customer use experience. Products offered to the consumer will be founded on continuing research at leading medical institutions using the latest scientific methods and technology. All products will be nature based and scientifically developed. Nerium SkinCare oversees the process from seed to finished product.

Nerium SkinCare's product formulation and production starts with the science developed at NBI's USA-based environmentally responsible and earth-friendly farming operations, where fields of naturally grown Nerium oleander plants provide the raw material for Nerium SkinCare's botanical extract. Transitioning from the Nursery environment, NBI now has 10 plus years of experience commercially growing the Nerium oleander plant to provide a renewable and dedicated source of biomass. Farming operations are considered all natural to meet the biomass standards required for biotechnology research and product formulation (without pesticides, etc.).

Nerium SkinCare's product formulation and product manufacturing are provided for by Don Smothers, President, CEO of Natural Technology Incorporated (Naturtech). Naturtech is a GMP manufacturing facility. Mr. Smothers has more than 40 years in the development and manufacturing of consumer products with more than 30 years of experience with Aloe Vera research, Aloe Vera industry affiliations, and Aloe Vera consumer products. In addition, Naturtech utilizes its proprietary naturally grown Aloe Vera processing technology, known as "cold processed, whole leaf aloe vera" with the NBI extraction process NBio-PL² ™.

Product formulation has focused on the key NAE-8 ™ extract components and can be enhanced with fragrance, coloration, strength, absorption/anti-absorption components, moisturizing components and any additional ingredients for target applications/markets. Dr. Newman's initial characterization and pharmacology research of the major biochemical and biological properties at the University of Texas M. D. Anderson Cancer Center has served as the basis for quality control for the production of the Nerium Extract and associated products. Production yield, product stability testing, Nerium Extract standardization, and clinical safety trials are ongoing, providing additional data for future regulatory requirements. The experience and ability to formulate and add additional ingredients to the multiple products required for Nerium SkinCare's success is in place.

Safety and Clinical Testing

Testing for product safety and clinical application was initiated with Science, Toxicology & Technology, Inc. (ST&T Research). ST&T Research is comprised of a group of prominent scientist, including M.D. and Ph.D. pharmacologists/toxicologist and research product development oriented physicians, scientist, and regulatory compliance specialists which include a legal team specializing in USA FDA/FTC/Customs regulations. ST&T Research provides product development, product compliance, regulatory compliance, clinical testing, and information and data for safety and efficacy.

Dr. Robert A. Newman who serves as a scientific advisor to Nerium SkinCare assisted by providing safety data from previous studies, experience from a FDA cancer trial at The University of Texas M. D. Anderson Cancer Center, and the analytical analysis for the determination of oleandrin (CG) in blood plasma. Nerium oleander is a known toxic plant that contains cardiac glycosides (CG) and therefore appropriate concerns for safety have to be demonstrated and confirmed for any new product.

ST&T Research initiated human studies on various skin disorders (1. age/liver spots, actinic keratosis (2. acne vulgaris (3. sunburn (4. fever blisters/cold sores. The Nerium test article application was first applied as a spot treatment, then larger areas of skin application with each new clinical study. Two (2) of these clinical studies (acne, sunburn) included comparison to well-known OTC products currently available to consumers.

Each study's primary end-point was to evaluate the Nerium test articles for safety/toxicity, a) Determine if the Nerium oleander CG metabolites were being absorbed through the skin, b) If so, how much, c) If there was any noticeable blood pressure or heart rate changes, and d) If there were changes in blood chemistry or organ system functions. In addition, subjects were observed for inflammation, rash, or tenderness possibly related to the cream application.

ST&T utilized blood chemistry and CBC analysis whereby a comparison was made of the participant's baseline results with measurements taken throughout the study. As an example, participant blood samples were taken on day one (1) (one hour after cream application), day seven (7), day fifteen (15), and on day thirty (30) of product use to test for oleandrin (CG) absorption and accumulation in the blood.

Analysis was non-eventful. The blood analysis showed all subjects within normal ranges, there were no detectable CG's in the blood and no adverse reactions noted. The cardiac glycosides contained in Nerium oleander extracts were NOT ABLE to penetrate the skin at detectable levels in the blood. With regard to efficacy, ST&T was surprised to find there were a statistically significant number of subjects reporting positive results since the Nerium SkinCare test article contained no "additives" like the OTC products.

Continuing research and trials for Nerium SkinCare formulations are planned for not only topical cosmetic formulations but also healthcare formulations. Nerium SkinCare believes it will continue to demonstrate safety and new effective uses of its formulas. Learn more – Clinical

Investigators: Science, Toxicology & Technology and its physicians / health care practitioners.

Sponsor: Nerium Biotechnology Inc. (NBI) / Nerium SkinCare, Inc.

New Product Development, Testing, and Launch

Nerium Skincare has formulated/developed its initial new product for market launch, NeriumAD™ an age–defying night cream. Exclusive distribution of NeriumAD™ is provided for in a licensing partnership with Nerium International, LLC.

Anti-aging skin creams are abundant in today's cosmetic marketplace. New ingredients that may provide additional efficacy are sought to improve existing products. The NeriumAD™ formulation is specifically designed for this market and provides two (2) such ingredients, NAE-8 ™ extract and a proprietary protein blend (collagen & elastin & glycosaminoglycans).

Clinical testing was provided by ST&T Research utilizing technology from the semi-conductor industry, now transferred to the skin care industry. Test subject outcomes included objective evaluation of changes in appearance of 'aging and sun damaged skin" of the face, using an advanced R&D model fluorescence spectroscopy skin analyzer (Moritex BTBP Clarity Pro system, San Jose, CA.) Learn more – Clinical and Product

Investigators: Science, Toxicology & Technology and its physicians / health care practitioners.

It took an average of 12 years for the best in the industry with multiple products in multiple countries to do what NeriumAD did in 1 year...with 1 product... in 1 country.

Now that is AMAZING!!!

Featured Product Information

1. Nerium Night Cream
2. Nerium Day Cream
3. Nerium Firm

About Me

I am a 43 year old mother of 1 teenage daughter. I have numerous job skills but love to make people feel good about themselves. Self esteem is huge in our personal and professional lives.

Product List

1. Nerium Night Cream 2. Nerium Day Cream 3. Nerium Firm

My Favorite Products

1. Nerium Night Cream
2. Nerium Day Cream
3. Nerium Firm

Keyword List

Nerium, skin, cream, anti-aging, age spots, sun damage, sun, wrinkle, pore size, home base, business opportunity, small business, work from home, cellulite, dimpling, youth, self esteem, younger looking, beauty, skin care, product